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The principal cytochrome P450 isoenzyme associated appears to be CYP2E1, with CYP1A2 and CYP3A4 as extra pathways. Close to eighty five% of an oral dose appears in the urine in 24 hours of administration, most since the glucuronide conjugate, with modest quantities of other conjugates and unchanged drug (see OVERDOSAGE) for toxicity facts.Clients a